It is anticipated that these guidelines would help health professionals to prevent extravasation during IV and central vein injection and to promote patient safety should extravasation occur in any case. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Cardiac Failure: Administer inotropic agents (isoproterenol, dopamine, or dobutamine) and diuretics. Available for Android and iOS devices. The site is secure. However, the study had only a small number of The risk of toxic reactions to this drug may be greater in patients with impaired renal or hepatic function. Physical incompatibilities (precipitate formation or cloudiness) were observed when diltiazem hydrochloride injection was infused in the same intravenous line with the following drugs: acetazolamide, acyclovir, aminophylline, ampicillin, ampicillin sodium/sulbactam sodium, cefamandole, cefoperazone, diazepam, furosemide, hydrocortisone sodium succinate, insulin (regular: 100 units/mL), methylprednisolone sodium succinate, mezlocillin, nafcillin, phenytoin, rifampin, and sodium bicarbonate. Nervous System: Dizziness, paresthesia Diltiazem extravasation. IV push over 10 minutes or IVPB as directed. Extravasation may occur if the administration of the drug is too quick, the medication is very acidic or basic, or there is an obstruction in the . Take the missed dose as soon as you remember. Fixed high-degree AV block should be treated with cardiac pacing. Sterile eugia 10 x 5 mL Single-Dose Vials, Rx only NDC 55150-426-01 You may also need frequent blood tests. Diltiazem is in a class of medications called calcium-channel blockers. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota. Writingoriginal draft: JTK, JYP, HJL, YJC. Diltiazem Keep diluted diltiazem hydrochloride injection refrigerated until use. An incident of extravasation must be correctly documented and reported. The guidelines described herein are based on the authors best practice for the management and prevention of the extravasation. Overdosage experience is limited. Duration of infusion longer than 24 hours and infusion rates greater than 15 mg/h have not been studied. Rifampin - Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. When treatment for hypotension was required, it generally consisted of administration of saline or placing the patient in the Trendelenburg position. Antidotes for the care of the extravasation. Reynolds PM, MacLaren R, Mueller SW, Fish DN, Kiser TH. Asymptomatic hypotension occurred in 4.3% of patients. Gastrointestinal: Anorexia, diarrhea, dysgeusia, dyspepsia, mild elevations of SGPT and LDH, thirst, weight increase