Cardinals 30, Eagles 27 -- Tim McManus, It's hard to know what the Jaguars are going to get from QB Blake Bortles each week, and this week may be even more of a mystery because the Jaguars may be without WR Marqise Lee because of a rib injury. -- David Newton, Bold prediction: San Francisco 49ers defensive end Nick Bosa will have three sacks in his second career game against the Panthers. This should be a prime spot for them to get on track, even with the uncertainty surrounding receiver Stefon Diggs. -- Jordan Raanan, Bold prediction: Minnesota will bench Diggs in Week 5 to send a message to the star receiver, especially after he missed practice for non-football injury-related reasons earlier in the week. Betting nugget: Philadelphia is 3-0 ATS against Pittsburgh since 2008. The Jaguars were leading the NFL in rush defense until giving up 210 yards and four rushing touchdowns in a loss at Philadelphia last weekend. Walder's pick: Eagles 23, Cardinals 20 When pressured, he ranks in the bottom of the league in QBR, completion percentage and yards per attempt. Rodgers hasn't topped 255 yards passing this season, and the Giants have the eighth-ranked pass defense. Click on each game for the game preview and CFN Prediction Week 5 NFL Expert Picks See Week 5 rankings. -- Mike DiRocco, Bold prediction: Texans wideout Brandin Cooks will have his best outing of the season with a 100-yard game. Read more. The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Buccaneers coach Todd Bowles explains handling of TE Cameron Brate's concussion, Veteran WR Cole Beasley retires after 11 NFL seasons, QB Kenny Pickett, Steelers begin work to get on 'same page', The Steelers' 2022 quarterback journey, and what happens next, LB Jamie Collins joins Patriots for fourth time, Swift likely out again vs. Patriots, source says, Bears designate WR N'Keal Harry for return; OL Cody Whitehair headed to IR, Inside Kelly Kleine's historic journey, from Vikings to Broncos, Justin Fields, Bears' struggling passing game looking for answers, Vikings riding ups and downs as Cousins learns new scheme, Dolphins' Mike McDaniel not fretting criticism over Tua Tagovailoa, Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded, Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, Browns' schedule gets difficult from now on, Garrett back at Browns practice for first time since car crash, Everything you need to know for the draft, The Seahawks have needed every bit of Geno Smith's unlikely success, Andy Dalton gave Saints' offense a spark, but bigger issues loom after 1-3 start, Saints' Alvin Kamara (rib) expects to play against Seahawks, Titans rookie WR Treylon Burks exits game with leg injury, Rivera OK with 'frustrations' amid 1-3 start, Commanders patient with Wentz despite rough stretch, RB Robinson returns to practice after being shot in robbery attempt, After loss, the Jaguars look to rebound against AFC South, How LSU and the SEC prepared Texans rookie Derek Stingley Jr. for the NFL, Former Jaguars QB Blake Bortles says he 'quietly' retired, Jimmie Ward year away from being among rarefied 49ers company, Mayfield struggles, but Panthers don't have another option, Nick Bosa says 49ers' defense has personnel to be 'best in the league', Mayfield takes blame for offense's struggles amid 1-3 start, Darnold's return from IR not close, coach Matt Rhule says, Miles Sanders' emergence makes the Eagles so much better, Defense keeps Cardinals afloat while offense figures it out, Jerry Jones: An 'injustice' not to give coach McCarthy credit. His five sacks this season match the total he recorded over the previous two seasons (21 games) combined. 198 days ago NFL Week 4 of the 2022-23 NFL season has come to a close. Jalen Ramsey to the Eagles: What are the realistic odds?