9-1-2010;10(3):238-246. View abstract. Take extra care if you are taking iron supplements. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. View abstract. No supplement is intended to treat, cure, or prevent disease. View abstract. We comply with the HONcode standard for trustworthy health information. Serotonin syndrome can even result in death. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Nat.Prod.Res 2005;19(6):567-571. Acta Nerv Super 1990;32(1):1-5. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. J Clin Lab Anal 2008;22:295-301. This information may not fit your specific health circumstances. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. I recommend taking it at bedtime for a better night's rest or you can take it during the day. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. Be sure to tell your doctor if you are breastfeeding. The concern would be blood pressure drops too lowif combining high blood pressure medications and ashwagandha. This is according to a recent review of case studies of liver damage caused by ashwagandha. Its botanical name is Withania somnifera and it is also known as "Indian ginseng . Ashwagandha And Lexapro (An Overview) | OptimistMinds The best time to take ashwagandha is at the time that works best for you. Learn about the uses and potential benefits of Ashwagandha including dosage guidelines, side effects, interactions and safety/efficacy ratings. Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. As with many other herbal supplements, little research is available on possible interactions. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days.