Langmuir 27:1528215291. Many people like the ease and convenience of taking a tablet or capsule these are also ideal for travelling. QSILICA PRO COLLAGEN: We would recommend seeking advice from your health practitioner before taking PRO COLLAGEN capsules during pregnancy or breastfeeding. In addition, it has the widest ranging surface area, and its aggregate size can be as small as the actual size of the primary particle. J Sol-Gel Sci Technol 102, 4162 (2022). Polym Chem 2:2771. https://doi.org/10.1039/c1py00426c, Wang D, Xu Z, Chen Z et al. VII. For example, 50nm particles can be concentrated to greater than 50 wt% solids while 10nm particles can only be concentrated to approximately 30 wt% solids before the suspension becomes too unstable. [13] Dal Zotto, M., Realdon, N., Ragazzi, E., Dalla Fini, G., Effects of two different kinds of silicon dioxide on release of drugs from suppositories: benzydamine hydrochloride. A low shear blender (gravity drop or mechanical mixers) is preferred to prevent the addition of excess energy into the blend. https://doi.org/10.1016/j.micromeso.2019.04.050, Allen LH, Matijevi E (1970) Stability of colloidal silica II. Effect of colloidal silica on rheological properties of common - PubMed PharmaCentral 2021 . https://doi.org/10.1039/d0nr09220g, Marques MRC, Loebenberg R, Almukainzi M (2011) Simulated biological fluids with possible application in dissolution testing. Spilled material should be collected without any dust being formed and placed in a suitable container. (2002) A review of non-DLVO interactions in environmental colloidal systems. Chemistry 22:1480614811. Finally, colloidal silicon dioxide is inert toward most active drug ingredients and excipients, so incompatibilities are extremely rare. https://doi.org/10.1016/j.micromeso.2010.11.013, Mosquera J, Garca I, Henriksen-Lacey M et al. [3] World Health Organization & Food and Agriculture Organization of the United Nations. Provided it is stored appropriately and as recommended, the material does not undergo any significant chemical changes, even after several decades. (2019) Mixed-charge pseudo-zwitterionic mesoporous silica nanoparticles with low-fouling and reduced cell uptake properties. This versatility stems from its high absorptive capacity, ability to improve flow, and low dust content, as outlined in the table below: When applied to pharmaceutical products, the above-listed Silica attributes provide the following functionalities: Thus, Colloidal silicon dioxide functions, in both solid and liquid dosage forms, as a: In tablets, capsules, and granules, Colloidal silicon dioxide is popularly used as a glidant and anti-adherent, where it allows powder formulations to efficiently flow on high-speed tablet presses.